Fig. 2: Simple and speculative schematic for the functional consequences of GRIN2A variants involved in schizophrenia. | Molecular Psychiatry

Fig. 2: Simple and speculative schematic for the functional consequences of GRIN2A variants involved in schizophrenia.

From: GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia

Fig. 2

Common variants, and GRIN2A loss of function (protein truncating) variants, are proposed to lead to reduced mRNA expression and thence lower NR2A subunit abundance, whereas GRIN2A missense variants result in NR2A subunits with aberrant electrophysiological properties. These NR2A-mediated impairments in NMDA receptor function interact with other glutamatergic risk genes and the many other pathways and processes involved in schizophrenia pathophysiology.

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