Fig. 4: TIMP2 is required for hippocampus-dependent memory function.
From: Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity
A Schematic of the novel location recognition assay. B Discrimination index for novel location recognition on day 2 for WT and TIMP2 KO mice (2–3 months of age, N = 11–12 mice per group). C Schematic of the contextual and cued fear-conditioning assay. D, E Freezing levels by interval and overall measured in the conditioned-fear context A in WT and TIMP2 KO mice (2-3 months of age, N = 11–12 mice per group). F Schematic diagram of modified Barnes maze with color coding for overall strategy classification. G Proportion of WT and TIMP2 KO mice using non-hippocampus-dependent (gray) and hippocampus-dependent (yellow) strategies during the testing trials (2–3 months of age, N = 9 mice per group). H Strategy utilization by WT and TIMP2 KO mice on day 3 of the Barnes Maze and corresponding (I) cognitive scores, ranked by strategy complexity for WT and TIMP2 KO mice on day 3 in the Barnes Maze. Data are represented as mean ± SEM. Student’s t test for two-group comparisons in (B, D, E), chi-square test in (H), and nested t-test (I) for trial and mouse levels. *P < 0.05, **P < 0.01. Data points represent individual mice.
