Fig. 2: Overview of group, treatment and interaction effects across all nodal metrics (betweenness-centrality, node degree and local efficiency).

The shade of colour represents the t-statistic for each region. Only regions surviving FDR-corrected significance threshold p < 0.05 shown. In the top panel depicting main effects of group, regions in purple and green depict lower and greater graph metrics (respectively) in CHR-P relative to healthy controls (HC). In the middle panel depicting treatment effects, regions in green and purple depict increases and decreases (respectively) in graph metrics under oxytocin (OT) relative to placebo (PL). Although significant, the brainstem (t = 2.34) is not depicted as it is not included in the ENIGMA visualisation template. In the lower panel depicting group x treatment interaction effects, regions in green depict where oxytocin increased (↑) graph metrics in the CHR-P group but decreased (↓) them in healthy controls; regions in purple depict where oxytocin decreased graph metrics in the CHR-P group but increased them in controls. All results are presented here irrespective of the metric; where there were effects in the same region in more than one nodal metric, the larger t-value is shown. All corresponding statistics are presented in Table 2 and individual figures for each metric are appended in Supplementary Figs. 2–4.