Fig. 1: Differential gene expression pathways in the hippocampus of children with ASD.
From: Molecular profiling of the hippocampus of children with autism spectrum disorder
A Volcano plot of DGE: ASD vs. non-ASD controls. On the x-axis is log fold change of genes in subjects with ASD compared to controls, points to the right of 0 represent genes that are increased, and points to the left of 0 genes that are decreased, in ASD compared to controls. Statistical significance is displayed on the y-axis, and p < 0.05 are labeled in blue. Select genes with both high fold change and significance are labeled. The top dozen GSEA Reactome analysis identified upregulated pathways, (including extracellular matrix organization and immune signaling pathways), and downregulated pathways involved in synaptic regulation in children with ASD (B). Similar top pathways were detected with GSEA GO BP analysis (C). Reactome tree and GO tree plots of pathways altered in children with ASD (D, E). GSEA GO enrichment plot of upregulated and downregulated pathways in children with ASD (F).
