Fig. 2: Association between subphenotypes in BD patients and polygenic risk scores of BD, schizophrenia and MDD in BD1 and BD2 cases in meta-analyses. | Molecular Psychiatry

Fig. 2: Association between subphenotypes in BD patients and polygenic risk scores of BD, schizophrenia and MDD in BD1 and BD2 cases in meta-analyses.

From: Key subphenotypes of bipolar disorder are differentially associated with polygenic liabilities for bipolar disorder, schizophrenia, and major depressive disorder

Fig. 2

Genetic profiles include polygenetic risk scores for bipolar disorder (BD-PRS), schizophrenia (SCZ-PRS), and major depressive disorder (MDD-PRS). The results of association tests for each cohort and meta-analyses are in Supplementary Tables S5–6, among which the results of meta-analyses were presented here. The regression models were the same as in the main analyses, with odds ratios (OR) reported for categorical variables in Panel A and Beta reported for continuous variable in Panel B. Psychotic symptoms during mood episodes was not tested because BD2 cases did not have this subphenotype. P < 0.004 (corrected for 12 tests in BD1 meta-analyses) and P < 0.005 (corrected for 9 tests in BD2 meta-analyses) are considered significant and marked with asterisk.

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