Fig. 4: IPA analysis of unique DEGs in the dorsal striatum of ASR, DSR, and AS rats. | Molecular Psychiatry

Fig. 4: IPA analysis of unique DEGs in the dorsal striatum of ASR, DSR, and AS rats.

From: Incubation of methamphetamine craving in punishment-resistant individuals is associated with activation of specific gene networks in the rat dorsal striatum

Fig. 4

The Venn diagram in (A) illustrates common and unique upregulated gene between 3 pairwise comparisons ASR vs (CT, DSR and AS). B Networks significantly enriched among 82 unique genes in the ASR vs DSR comparison. C The Venn diagram illustrates the distribution of 50 genes with the highest fold in the ASR compared to DSR or AS rats. D IPA analysis shows that 34 shared between ASR vs AS and DSR vs AS comparisons are involved in processes that mediate memory, learning, cognition, and METH dependence. Cognitive impairments are common in patients with MUD. E The Venn diagram illustrates the number of genes that are commonly and uniquely located in 3 pairwise comparisons of AS vs (CT, ASR and DSR). F IPA shows networks involving 101 genes that are common in AS vs CT, AS vs ASR, and AS vs DSR comparisons (71 genes) and in AS vs ASR and AS vs DSR comparisons (31 genes). These genes are involved in amphetamine delusional disorder, cognitive impairments, and addictive behaviors. The red color indicates upregulated genes, and the blue color represents interacting genes.

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