Fig. 2: Pathway polygenic scores (pPGS) based on four main neurotransmitter systems.
From: Association of neurotransmitter pathway polygenic risk with specific symptom profiles in psychosis
A KEGG [58], AmiGO [60], and REACTOME [59] were searched for genes associated with glutamatergic, GABAergic, dopaminergic, and serotonergic neurotransmission. B pPGS developed from these gene sets showed substantial correlation in psychosis subjects when regressing against the first ten genetic principal components. Statistically significant correlations (p < 0.05) are denoted with an asterisk. C While no pPGS significantly separated overall psychosis cases from controls, D glutamate and GABA pPGS separated SZ cases specifically from controls, though these findings do not pass FDR < 0.10.
