Fig. 2: Psychiatric hospitalization burden.

a The psychiatric hospitalization burden for the four major psychotic disorders according to the diagnostic hierarchical model, where the highest ranked psychotic disorder was considered the current lifetime diagnosis. The y-axis shows the proportion hospitalized due to a psychiatric diagnosis in each group and the x-axis shows the age at event. Individuals with schizophrenia had the highest overall burden compared to the lower ranking diagnoses (β = 0.65, p = 3.26e-186). b Associations between endpoints often thought to reflect general functioning and their association to the average yearly psychiatric hospitalization burden. The results show that an increased hospitalization burden was associated with a poor outcome for all endpoints, suggesting that the measurement can serve as a proxy to track disease-severity. Note, the analysis was constrained to individuals with schizophrenia (n = 5479) to not be influence by the cohort’s diagnostic composition. (Parameters have been named to make the direction of effect intuitive; n denotes the number of individuals with non-missing data for the specific endpoint; *Adjusted Paired Associates Learning (PAL) errors, a part of the CANTAB suit to assess cognitive function.).