Fig. 2: Three-way interaction between stressful life events (LEQ) and childhood maltreatment (CTQ) on GMV change in the middle frontal/precentral/postcentral gyri between MDD patients with and without an episode during the 2-year interval and HCs. | Molecular Psychiatry

Fig. 2: Three-way interaction between stressful life events (LEQ) and childhood maltreatment (CTQ) on GMV change in the middle frontal/precentral/postcentral gyri between MDD patients with and without an episode during the 2-year interval and HCs.

From: Neural foundation of the diathesis-stress model: longitudinal gray matter volume changes in response to stressful life events in major depressive disorder and healthy controls

Fig. 2

Figure illustrates the moderating effect of CTQ on the relationship between LEQ and GMV change in the middle frontal/precentral/postcentral gyri in MDD patients with at least one depressive episode. No significant moderating effect was observed in MDD patients without an episode or HCs during the 2-year interval. The β1 value represents the simple effect of LEQ on GMV change, β2 value represents the two-way interaction between LEQ and CTQ on GMV change, and β3 value represents the three-way interaction between LEQ, CTQ, and recurrence group (MDD patients with an episode during the 2-year interval, MDD patients without an episode, and HCs) on GMV change. *Interactions were statistically significant at p < 0.05. **Interactions were statistically significant at p < 0.01.

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