Fig. 4: Interactions between Catechol-O-Methyltransferase single nucleotide polymorphism rs4680 and sex on DTNBP1 gene expression separately for age groups and brain regions.
Error bars showing the interactions resulted from separate two-way analyses of variance between COMT and sex on DTNBP1 gene expression across age groups, that is, the perinatal period (up to the age of 6 years), juvenile period (between 12 and 25 years of age), younger adulthood (25-50 years of age), and the older adulthood (above 50 years of age) and separately for caudate, dorsolateral prefrontal cortex and hippocampus. Significant interactions have been found between sex and the COMT rs4680 on DTNBP1 expression for DLPFC in young adults (F(2,87) = 3.34, *puncorr = 0.040), and caudate in the perinatal age group (F(1,19) = 10.22, **puncorr = 0.006). All other analyses of variance yielded no significant interaction effects between sex and COMT rs4680 on DTNBP1 expression, all puncorr > 0.05 Abbreviations: F female, M male, y. age in years, DLPFC dorsolateral prefrontal cortex.
