Fig. 4: iMGL expression profile and pathway analysis.
From: Genetic contribution to microglial activation in schizophrenia
a Overview of differentially expressed genes (DEGs) in different comparisons. b Venn diagram of shared DEGs between HT vs. CTRL and ST vs. CTRL. Ingenuity Pathway Analysis (IPA) canonical pathways (c) from ST vs. CTRL and (d) HT vs. CTRL comparisons. Cutt-offs: Fold change > abs 2, adjusted p < 0.05. e Downregulated and (f) upregulated Gene Ontology (GO) Molecular function terms from ST vs. CTRL comparison and (g) downregulated terms from HT vs. CTRL comparison. CTRL healthy individuals, ST affected twin, HT healthy twin. RNAseq n = 4 lines in each group.
