Fig. 5: Hypoexcitability of neurons derived from schizophrenia patients.

A The neurons derived from the schizophrenia patients produced fewer evoked action potentials than the neurons derived from the other 2 groups. The neurons derived from the unaffected twin siblings (depressive disorder) produced more evoked action potentials than those from the affected twin siblings but fewer than the neurons derived from the healthy twin pairs. On the left are representative trace recordings. On the right, the averages of the total evoked potentials (see Methods) are presented. B Spike shape analysis. The spike width was wider in the neurons derived from the affected twin siblings compared to the other 2 groups. The spike amplitude was smaller in the neurons derived from the affected twin siblings compared to the neurons derived from the other 2 groups. There was no significant change in the threshold for eliciting an action potential between the 3 groups. The amplitude of the fast afterhyperpolarization (AHP) was smaller in the neurons derived from both the affected twin siblings and the unaffected twin siblings. The data acquired in this figure was obtained from 3-4 differentiation cycles for each of the lines. * represents p < 0.05, ** represents p < 0.01, *** represents p < 0.001, **** represents p < 0.0001.