Fig. 6: Three groups were observed when analyzing neurophysiological features throughout the maturation of the DG granule neurons.

A The capacitance measurements of the 3 groups (neurons derived from the affected twin siblings, neurons derived from the unaffected co-twin siblings (depressive disorder), and neurons derived from the healthy twins) at 4 weeks and 2 months. B The input conductance measurements of the 3 groups at 4 weeks and 2 months. C The resting membrane potential of the 3 groups at 4 weeks and 2 months. D The sodium currents of the 3 groups at 4 weeks. E The sodium currents of the 3 groups at 2 months. F The sodium currents at -20 mV of the 3 groups at 4 weeks and 2 months. G The potassium currents of the 3 groups at 4 weeks. H The potassium currents of the 3 groups at 2 months. I The potassium currents at 20 mV of the 3 groups at 4 weeks and 2 months. J A representative example trace of the sodium and potassium currents acquired in voltage clamp mode of a control neuron. K A representative example trace of the sodium and potassium currents acquired in voltage clamp mode of a co-twin neuron. L A representative example trace of the sodium and potassium currents acquired in voltage clamp mode of a schizophrenia neuron. The data acquired in this figure was obtained from 3-4 differentiation cycles for each of the lines.