Fig. 6: Causal relationship between pGenes and SCZ.
From: Genetic regulation of human brain proteome reveals proteins implicated in psychiatric disorders
A Schematic diagram showing three putative mechanistic controls of a QTL: causality, pleiotropy, and genetic linkage. B Forest plots showing effect sizes of 4 and 19 SCZ GWAS loci causally controlled by pGenes and eGenes, respectively. The causality relationship was estimated by the SMR/HEIDI method. Center values mark effect size point estimates, error bars the 95% confidence intervals. C LocusZoom plot showing an example of an SCZ GWAS is controlled by a cis-pQTL. D LocusZoom plot showing an example of an SCZ GWAS is controlled by a cis-eQTL.
