Fig. 2: Interaction effect between TNF-α PGS and diagnosis on processing speed. | Molecular Psychiatry

Fig. 2: Interaction effect between TNF-α PGS and diagnosis on processing speed.

From: The interplay between polygenic score for tumor necrosis factor-α, brain structural connectivity, and processing speed in major depression

Fig. 2

Note. The figure depicts the significant interaction effect between polygenic score for tumor necrosis factor-α (TNF-α PGS) and diagnosis on processing speed. Patients with acute major depressive disorder (MDDa) showed a negative association between TNF-α PGS and processing speed, whereas no association was found in patients with a partially (MDDpr) or fully remitted (MDDfr) depressive episode and healthy controls (HC). Processing speed (z-score) was calculated from five tests of a neuropsychological test battery using exploratory principal component analysis. A more positive processing speed score represents higher processing speed performance.

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