Fig. 3: Brain structural connectivity mediates the association between polygenic score for tumor necrosis factor-α (TNF-α PGS) and processing speed in acutely depressed patients. | Molecular Psychiatry

Fig. 3: Brain structural connectivity mediates the association between polygenic score for tumor necrosis factor-α (TNF-α PGS) and processing speed in acutely depressed patients.

From: The interplay between polygenic score for tumor necrosis factor-α, brain structural connectivity, and processing speed in major depression

Fig. 3

The figure depicts the mediation model with TNF-α PGS as a predictor variable, structural brain connectivity (measured by mean fractional anisotropy) as a mediator variable, and processing speed as an outcome variable in acutely depressed patients. A higher processing speed score represents higher processing speed performance. Unstandardized coefficients and standard errors for each path of the mediation model are presented. Note that c represents the direct effect and c‘ the indirect effect. * indicates significance at p < 0.05.

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