Table 1 Demographic and clinical characteristics of the sample.

From: The interplay between polygenic score for tumor necrosis factor-α, brain structural connectivity, and processing speed in major depression

Variable

HC (n = 743)

MDDfr (n = 198)

MDDpr (n = 177)

MDDa (n = 284)

Statistic

p-value

Siga

Sex (male: female)

261:482 (35:65%)

52:146 (26:74%)

69:108 (39:61%)

104:180 (37:63%)

8.18

0.042

−

Age

33.95 ± 12.54

36.11 ± 12.94

36.30 ± 12.90

36.30 ± 13.47

3.64

0.012

−

BMI

24.13 ± 4.40

25.10 ± 5.11

26.43 ± 5.80

26.23 ± 6.04

17.68

<0.001

B, C

TNF-α PGS

36.10 ± 0.07

36.09 ± 0.08

36.09 ± 0.08

36.10 ± 0.07

0.80

0.500

−

Processing speed

0.26 ± 0.92

-0.12 ± 0.94

−0.25 ± 0.91

-0.43 ± 1.09

41.93

<0.001

A, B, C, E, F

HDRS-21

1.41 ± 2.10

3.40 ± 3.45

7.93 ± 5.67

14.44 ± 6.29

759.28

<0.001

A, B, C, D, E, F

Hospitalizations

−

1.03 ± 1.41

1.69 ± 2.14

1.88 ± 2.11

11.62

<0.001

D, E

Comorbidities (yes: no)

−

67:131 (34:66%)

77:100 (43:57%)

146:138 (51:49%)

14.64

<0.001

E

Medication load

−

0.60 ± 0.98

1.50 ± 1.44

1.84 ± 1.50

50.54

<0.001

D, E, F

  1. Except for sex and comorbidities, mean values and standard deviations are shown. Test statistics and p values were derived from general linear models (GLM) or Chi-square tests. Processing speed was calculated from five tests of a neuropsychological test battery using an exploratory principal component analysis.
  2. TNF-α PGS Polygenic score for tumor necrosis factor-α, BMI Body mass index, HDRS-21 Hamilton Depression Rating Scale 21 (total score), HC healthy controls, MDDfr patients with a fully remitted episode of major depressive disorder, MDDpr patients with a partially remitted episode of MDD, MDDa patients with an acute episode of MDD.
  3. aLetters indicate significant (i.e., p < .05) differences in Bonferroni corrected post-hoc tests between HC and MDDfr (A), HC and MDDpr (B), HC and MDDa (C), MDDfr and MDDpr (D), MDDfr and MDDa (E), and MDDpr and MDDa (F).
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