Fig. 1: 40 Hz light flicker alleviated social novelty deficit in 16p11.2 deletion female mice.

a The movement trajectory chart of mice in the open field test of all groups. Dashed box: center area. b the distance traveled in the open field. c time in the center in the open field (Groups: WT, 16p, 16p + 40Hz-7d, 16p + 40Hz-14d; n = 8 mice in each group). d The trajectory chart of mice in the three-chamber test. S1: familiar mouse, S2: novel mouse. e Sociability index in the three-chamber test. f Social novelty preference index in three-chamber test (WT: n = 7 mice, 16p: n = 12 mice, 16p + 40Hz-7d: n = 11 mice, 16p + 40Hz-14d: n = 11 mice). ns, not significant, *P < 0.05, ***P < 0.001, unpaired t test or one-way ANOVA with Tukey’s post hoc test.