Fig. 4: 40 Hz light flicker induces the adenosine release. | Molecular Psychiatry

Fig. 4: 40 Hz light flicker induces the adenosine release.

From: Adenosine mediates the amelioration of social novelty deficits during rhythmic light treatment of 16p11.2 deletion female mice

Fig. 4

a The expression of adenosine sensor in the unilateral PFC (scale bar: 1 mm). b Representative trace of adenosine signaling during optical fiber recording. c Quantification of the amplitude of adenosine signaling before (10 min) and during 40 Hz light flicker (10 min). d Quantification of the frequency of adenosine signaling before and during 40 Hz light flicker (n = 3 mice). e Quantification of the level of adenosine in PFC of WT female mice before and after one hour of 40 Hz light flicker (n = 3 mice). f Representative traces of sEPSC in three groups, scale bar: 20 mV/0.5 s. g Quantification of sEPSC frequency. h Quantification of sEPSC amplitude (aCSF: n = 12 cells from 4 mice, Ade (10 mM): n = 9 cells from 3 mice, Ade+DPCPX (0.3 mM): n = 14 cells from 3 mice). ns, not significant, *P < 0.05, **P < 0.01, unpaired t-test, Kruskal-Wallis test with Dunn’s post hoc test, and one-way ANOVA with Tukey’s post hoc test.

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