Table 2 Association of known WMH risk variants and global NODDI markers in young adults (i-Share study, n = 1 758).

From: Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel disease

       

NDI

ODI

ISOVF

SNP

Locus

Pos

Nearest gene

A1

A0

FreqA1

Z

p

Z

p

Z

p

Genetic risk score (23 SNPs)

   

−3.83

1.28E-04a

1.09

2.76E-01

0.99

3.22E-01

rs73923006

2p21

43132224

HAAO

G

C

0.82

−0.01

9.95E-01

2.10

3.59E-02

1.61

1.08E-01

rs17205972

5q14.3

82859065

VCAN

T

G

0.19

−5.68

1.32E-08a

0.02

9.81E-01

2.46

1.38E-02

rs71471298

10q24.33

105507145

SH3PXD2A-AS1

T

C

0.11

−2.61

9.18E-03

0.11

9.16E-01

0.43

6.70E-01

rs10786772

10q24.33

105610326

SH3PXD2A

G

A

0.69

−1.68

9.25E-02

0.44

6.61E-01

2.40

1.64E-02

rs55940034

13q34

111043309

COL4A2

G

A

0.31

2.14

3.25E-02

0.79

4.30E-01

−0.66

5.07E-01

rs1948948

16q12.1

51442679

SALL1

C

T

0.58

0.12

9.07E-01

0.51

6.12E-01

−2.67

7.59E-03

rs6503417

17q21.31

43144218

NMT1

C

T

0.63

−3.41

6.46E-04a

−0.41

6.81E-01

2.00

4.56E-02

  1. A1: effect allele (aligned with allele increasing WMH risk); A0: non-effect allele; Freq: frequency of A1; Z: Z-score defined as Beta of A1 / Standard error.
  2. Only results at least nominally significant with one of the global NODDI markers are presented.
  3. Nominally significant results are in bold.
  4. NDI Neurite Density Index, ODI Orientation Dispersion Index, ISOVF Isotropic Volume Fraction.
  5. aSignificant results (p < 2 × 10-3 for SNPs; p < 1.27 × 10-3 for genetic risk score).
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