Table 1 Sociodemographic, clinical, and psychological characteristics of study cohorts.

From: Disease-specific alterations in central fear network engagement during acquisition and extinction of conditioned interoceptive fear in inflammatory bowel disease

 

UC (N = 20)

HC (N = 25)

IBS (N = 23)

Group comparison

t

p

d

Age

39.20 ± 2.84

42.04 ± 2.61

46.91 ± 2.28

UC vs. HC

0.34

0.467

0.22

    

UC vs. IBS

2.14

0.038*

0.66

BMI

23.03 ± 0.68

23.03 ± 0.56

23.13 ± 0.84

UC vs. HC

0.01

0.996

0.02

    

UC vs. IBS

0.09

0.926

0.03

GI symptoms

9.45 ± 1.43

3.68 ± 0.61

15.09 ± 1.02

UC vs. HC

3.71

0.001**

1.20

    

UC vs. IBS

3.27

0.002**

1.00

HADS total score

10.45 ± 1.02

6.76 ± 0.86

15.09 ± 1.27

UC vs. HC

2.78

0.008**

0.83

    

UC vs. IBS

2.79

0.008**

0.85

HADS anxiety

10% clinical

0% clinical

39% clinical

    
 

6.95 ± 0.69

3.68 ± 0.50

9.09 ± 0.68

UC vs. HC

3.94

<0.001***

1.18

    

UC vs. IBS

2.19

0.034*

0.67

HADS depression

0% clinical

0% clinical

13% clinical

    
 

3.50 ± 0.54

3.08 ± 0.50

6.00 ± 0.69

UC vs. HC

0.57

0.571

0.17

    

UC vs. IBS

2.80

0.008**

0.85

BPI pain severity

5.53 ± 1.82†

1.20 ± 0.68

9.48 ± 1.82

UC vs. HC

2.23

0.036*

0.75

    

UC vs. IBS

1.52

0.136

0.47

BPI pain interference

8.95 ± 3.61†

1.88 ± 1.08

14.04 ± 3.40

UC vs. HC

1.87

0.075

0.64

    

UC vs. IBS

1.02

0.312

0.32

TICS chronic stress

20.85 ± 2.08

15.68 ± 2.08

25.17 ± 1.79

UC vs. HC

1.87

0.069

0.56

    

UC vs. IBS

1.75

0.089

0.53

  1. Sociodemographic, clinical, and psychological characteristics of study cohorts based on independent sample t-tests comparing patients with ulcerative colitis (UC) with healthy controls (HC) and with irritable bowel syndrome (IBS) as patient comparison group. Data are shown as mean ± standard error of the mean. For HADS anxiety and depression subscales, the percentage of participants (within groups) presenting with clinically relevant scores, i.e., with scores exceeding the published threshold of ≥11, is additionally provided (% clinical). Note that in all groups, pre- and postmenopausal women were represented (UC: 13 premenopausal, 10 using hormonal contraceptives; HC: 15 premenopausal, 6 using hormonal contraceptives; IBS: 12 premenopausal, 3 using hormonal contraceptives).
  2. BMI body mass index, BPI Brief Pain Inventory, HADS Hospital Anxiety and Depression Scale, TICS Trier Inventory for Chronic Stress, UC ulcerative colitis.
  3. †N = 19. *p < 0.05, **p < 0.01, ***p < 0.001.
Back to article page