Table 2 Differential neural responses to conditioned predictors of interoceptive pain during acquisition and extinction phases.

From: Disease-specific alterations in central fear network engagement during acquisition and extinction of conditioned interoceptive fear in inflammatory bowel disease

Contrast

ROI

H

MNI coordinates

t

pFWE

kE

x

y

z

ACQ

UC < HC

Early ACQ

–

–

–

–

–

–

–

–

Late ACQ

Amygdala

L

−28

−6

−18

3.66

0.011

24

 

Hippocampus

L

−26

−6

−20

3.96

0.019

7

 

Putamen

R

34

8

−2

4.06

0.015

8

UC < IBS

Early ACQ

–

–

–

–

–

–

–

–

Late ACQ

Amygdala

L

−28

0

−28

3.49

0.020

3

 

dorsal aINS

R

34

12

4

3.76

0.029

6

 

Putamen

L

−32

−6

4

3.73

0.041

6

  

R

34

8

−2

4.34

0.009

17

EXT

UC < HC

–

–

–

–

–

–

–

–

UC < IBS

Amygdala

L

−24

−6

−12

3.57

0.018

32

 

ventral aINS

L

−38

4

−10

3.83

0.015

6

 

Thalamus

R

4

−26

6

4.13

0.016

5

  1. Group differences in differential blood oxygen level dependent (BOLD) responses induced by conditioned interoceptive pain predictors (ΔCSVISC: CS+VISC > CS−) during interoceptive fear acquisition and extinction. Results of voxel-based analyses in region of interest analyses are provided, and exact unilateral p values are given (all pFWE < 0.05). For supplemental results of an analysis excluding UC treated with TNF-α blocker (N = 2) or azathioprine (N = 2), see S2.1; for results with HADS total score as covariate of no interest, see S2.2; for results of analyses on exteroceptive pain predictors, see S2.3.
  2. ACQ acquisition, aINS anterior insula, CS conditioned stimulus, EXT extinction, FWE family-wise error, H hemisphere, HC healthy controls, IBS irritable bowel syndrome, MNI Montreal Neurological Institute, ROI region of interest, UC ulcerative colitis.
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