Fig. 5: Four-way decomposition of the association between Poor Oral Health Problems (POHP) and brain white matter microstructural integrity metrics (Tract-specific FA, MD, ICVF, ISOVF, OD, z-scored) by the single principal component of selected plasma proteomic biomarkers (k = 2: GDF15 and WFDC2), overall (N = 4663): UK Biobank 2006–2021. | Molecular Psychiatry

Fig. 5: Four-way decomposition of the association between Poor Oral Health Problems (POHP) and brain white matter microstructural integrity metrics (Tract-specific FA, MD, ICVF, ISOVF, OD, z-scored) by the single principal component of selected plasma proteomic biomarkers (k = 2: GDF15 and WFDC2), overall (N = 4663): UK Biobank 2006–2021.

From: Mediating and moderating effects of plasma proteomic biomarkers on the association between poor oral health problems and brain white matter microstructural integrity: the UK Biobank study

Fig. 5

A DTI metrics; B NODDI metrics. ereri_cde excess relative risk due to neither mediation nor interaction or controlled direct effect, ereri_intmed excess relative risk due to mediated interaction or mediated interaction, ereri_intref excess relative risk due to interaction only or interaction referent, ereri_pie excess relative risk due to mediation only or pure indirect effect, pct_cde percent of total effect that is controlled direct effect, pct_intmed percent of total effect that is mediated interaction, pct_intref percent of total effect that is interaction referent, pct_pie percent of total effect that is pure indirect effect, POHP Poor Oral Health Problems, tereri (or total excess relative risk), UK United Kingdom. See supplementary Table 5 for protein abbreviations. Models were adjusted for baseline age, sex, race/ethnicity, household size, SES z-score and LE8 total score. Other Protein abbreviations are found at https://www.ncbi.nlm.nih.gov/gene/.

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