Table 2 Poor oral health problems (POHP) and brain white matter microstructural integrity probed using FA, MD, ICVF, ISOVF and OD MRI parameters (mean values across tracts), overall and by sex: OLS multiple linear regression models; UK biobank 2006–2021a,b.

From: Mediating and moderating effects of plasma proteomic biomarkers on the association between poor oral health problems and brain white matter microstructural integrity: the UK Biobank study

 

X = POHP, yes vs. no

PPOHP

β ± SE

Overall, N = 5089

 Y = FAmean

−0.0027 ± 0.00089

0.002

 Y = MDmean

+3.21e−06 ± 1.37e−06

0.019

 Y = ICVFmean

−0.0021 ± 0.0013

0.092

 Y = ISOVFmean

+0.0013 ± 0.0006

0.019

 Y = ODmean

+0.0006 ± 0.0004

0.14

Men, N = 2368

 Y = FAmean

−0.0014 ± 0.0012

0.25

 Y = MDmean

2.87e−06 ± 1.93e−06

0.13

 Y = ICVFmean

−0.00022 ± 0.00180

0.91

 Y = ISOVFmean

+0.0020 ± 0.0008

0.008

 Y = ODmean

+0.0003 ± 0.0007

0.65

Women, N = 2721

 Y = FAmean

−0.0041 ± 0.0012

0.001

 Y = MDmean

3.60e−06 ± 1.97e−06

0.067

 Y = ICVFmean

−0.0043 ± 0.0018

0.017

 Y = ISOVFmean

+0.00051 ± 0.0008

0.52

 Y = ODmean

+0.0009 ± 0.0005

0.077

  1. FA Fractional Anisotropy, ICVF Intracellular Volume Fraction, ISOVF Isotropic Volume Fraction, LE8 Life’s Essential 8, MD Mean Diffusivity, OD Orientation Dispersion, OLS Ordinary Least Square, Pd Periodontal Disease, POHP Poor Oral Health Problems, UK United Kingdom.
  2. aAll linear regression models were adjusted for baseline age, sex, race/ethnicity, household size, SES z-score and LE8 total score.
  3. bP for null hypothesis that β = 0, z-test from linear regression model.
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