Fig. 4: Transcriptome-wide meta-analysis of NAc and AMY data.

Meta-Analysis of the transcriptome-wide gene expression data from NAc and AMY from humans (A–F) and rodents (G, H) identified by Stouffer’s p-value combination with FDR < 0.05 as threshold for significant DEGs. Transcripts with FDR < 0.05 and log2 fold-change (FC) > 0.5 are highlighted in red; DEGs with FDR < 0.05 and FC < 0.25 are highlighted in blue; DEGs with FDR > 0.05 and FC > 0.25 are highlighted in green; DEGs with FDR > 0.05 and FC < 0.5 for humans and FC < 0.3 are highlighted in gray. A Gene expression pattern of the transcriptome-wide meta-analysis in human NAc. B Overlapping transcripts derived from human NAc original studied and the meta-analysis (FDR < 0.1). C Gene expression pattern of the transcriptome-wide meta-analysis in human AMY. D Overlapping transcripts derived from human AMY original studied and the meta-analysis (FDR < 0.1). E Venn diagram depicting the interspecies comparison considering the DEGs with FDR < 0.05 across the human PFC, NAc and AMY meta-analysis results. F Five DEGs have been detected to be consistently up-regulated across these brain regions: EDN, FKBP5, GADD45A, SERPINA3, and SLC7A2. G Gene expression pattern of the transcriptome-wide meta-analysis in rodent NAc. H Gene expression pattern of the transcriptome-wide meta-analysis in rodent AMY. Considering a threshold of FDR < 0.05, no DEGs were detected for both rodent NAc and AMY meta-analysis.