Fig. 5: Integrative analysis of AUD transcriptomics and proteomics data to obtain direct effects of the mRNA alterations identified in the meta-analysis on the protein level.

Since RRHO only allows inclusion of identically named targets, this analysis comprised 4,685 transcripts and their respective protein homolog. A Enrichment plot of stratified RRHO considering all four possibilities of concordant and discordant overlaps. Top left quadrant represents up-regulated gene expression and down-regulated protein expression, top right quadrant represents concordant down-regulation of gene and protein expression, bottom left quadrant represent concordant up-regulation of gene and protein expression and bottom right quadrant represents down-regulated gene expression and up-regulated protein expression. 1,701 transcripts (36.3%) were dysregulated into the same direction as their respective protein (representation factor:1.5, p < 1.34e-117). B GSEA of the overlapping transcripts. C Venn diagram depicting transcript-protein overlaps that are concordantly up-regulated. D Venn diagram depicting transcript-protein overlaps that are concordantly down-regulated.