Fig. 1: Regions of decreased gray matter volume in persons who died by suicide compared to persons who died by other methods.
From: Magnetic resonance imaging of regional gray matter volume in persons who died by suicide
The axial-oblique slices show clusters of lower gray matter volume in the suicide group at p < 0.005, uncorrected. The right hemisphere is shown on the right side of the figure, the numbers under the images are the mm in the z-plane for the slice in Montreal Neurological Institute (MNI) Atlas, and the color bar shows the range of z-score values. All clusters survived the significance threshold set to p < 0.05 family wise error correction with the exception of the right orbital and rostromedial prefrontal cortex regions (anterior-most cluster shown on slices z = −16mm and -8mm) that showed a trend towards significance (voxel-level threshold of p < 0.005 with a cluster threshold of 20 voxels). Regions of significantly decreased gray matter volume included ventral anterior cingulate cortex (VACC) (bilateral Brodman Area, BA, 25), left OFC (BA 47) and bilateral insula, temporopolar cortex (BA 38), parahippocampal gyrus, thalamus, ventral striatum, amygdala, as well as bilateral posterior cingulate cortex (BA 31), precuneus (BA 7), temporal and occipital association areas (BAs 18,19), brainstem and cerebellum, and right parietal cortex (BA 40).
