Fig. 1: Differentially expressed transcripts (FDR p-adjusted <0.1) in CRP-based group comparisons. | Molecular Psychiatry

Fig. 1: Differentially expressed transcripts (FDR p-adjusted <0.1) in CRP-based group comparisons.

From: Transcriptomic profiles in major depressive disorder: the role of immunometabolic and cell-cycle-related pathways in depression with different levels of inflammation

Fig. 1

A UpSet plots to summarise key differentially expressed (DE) transcripts. These panels summarise the DE transcript overlap between comparisons for up-or down-regulated DE transcripts (in black), for down-regulated DE transcripts (in blue) and, upregulated DE transcripts (in red). In each panel, the bottom left horizontal bar graph labelled “Set size” shows the total number of DE transcripts per comparison. The circles in each panel’s matrix represent what would be the different Venn diagram sections (unique and overlapping DE transcripts). Connected circles indicate a certain intersection of DE transcripts between comparisons. The top bar graph in each panel summarises the number of DE genes for each unique or overlapping combination. In the top left panel, for example, the first vertical bar shows those DE transcripts that are unique to MDD with CRP > 3 mg/L vs. CRP < 1 mg/L (1508 DE transcripts). The second shows those DE transcripts that are shared only between MDD with CRP > 3 mg/L vs. CRP < 1 mg/L and MDD with CRP > 3 mg/L vs. controls (457 DE transcripts). B, C, D Volcano plots of RNA-seq expression analysis (C, D MDD with CRP <1 mg/L vs. controls with CRP <1 mg/L). Each dot represents a transcript comparing the conditions stated in the heading. The horizontal line corresponds to a Benjamini-Hochberg FDR-adjusted significance value of <0.1. The vertical lines in D correspond to a log2 FC value of |0.26| corresponding to an FC value of |1.2|.

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