Fig. 4: Schematic representation of canonical pathways in group comparisons. | Molecular Psychiatry

Fig. 4: Schematic representation of canonical pathways in group comparisons.

From: Transcriptomic profiles in major depressive disorder: the role of immunometabolic and cell-cycle-related pathways in depression with different levels of inflammation

Fig. 4

Schematic representation of the different pathways involved in group differences A in the CRP-based and B in the treatment-based MDD groups and all MDD cases compared with controls and one another. Gene transcripts have been selected based on p <0.05 and FC > | 1.2 | . The groups analysed in different comparisons are written above the respective box, activation or inhibition refers to the first group. Each box contains pathways for a single comparison, ordered based on p-values (lower on the top and higher on the bottom). Orange indicates a predicted activation of the pathway (positive z-scores), blue a predicted inhibition (negative z-scores); the intensity of colours reflects the z-score values. Canonical pathways have been selected based on p < 0.05 and z-scores ≥ |2|.

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