Fig. 1: Regulation of energy balance by MC4R signaling in the hypothalamus and associated approved therapeutic agents. | Molecular Psychiatry

Fig. 1: Regulation of energy balance by MC4R signaling in the hypothalamus and associated approved therapeutic agents.

From: Obesity: exploring its connection to brain function through genetic and genomic perspectives

Fig. 1

ADCY3 adenylate cyclase 3, AgRP agouti-related peptide, BDNF brain derived neurotrophic factor, GLP1 glucagon like peptide 1, GLP1R glucagon like peptide 1 receptor, KSR2 kinase suppressor of ras 2, LHA lateral hypothalamu, MC4R melanocortin-4 receptor, MRAP2 melanocortin 2 receptor accessory Ppn 2, MSH melanocyte-stimulating hormone, NTS nucleus tractus solitarius, PCSK1 proprotein convertase subtilisin/kexin type 1, POMC proopiomelanocortin, SIM1 SIM BHLH transcription factor 1, TRKB tropomyosin-related kinase B, VMH ventromedial nucleus of the hypothalamus.

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