Fig. 2: Comparative overview of brain regulation of energy balance in monogenic versus polygenic obesity. | Molecular Psychiatry

Fig. 2: Comparative overview of brain regulation of energy balance in monogenic versus polygenic obesity.

From: Obesity: exploring its connection to brain function through genetic and genomic perspectives

Fig. 2

Monogenic obesity is characterized by disruptions in the hypothalamic circuits responsible for appetite control, leading to hyperphagia. Contrastingly, polygenic obesity implicates brain regions such as the substantia nigra and the insula, which are associated with addiction and reward processing.

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