Fig. 2: Heatmap visualization of the top 40 differentially expressed proteins in CSF when assessed with mass spectrometry. | Molecular Psychiatry

Fig. 2: Heatmap visualization of the top 40 differentially expressed proteins in CSF when assessed with mass spectrometry.

From: Three cases with chronic obsessive compulsive disorder report gains in wellbeing and function following rituximab treatment

Fig. 2

A A Heatmap visualization of the top 40 differentially expressed proteins in CSF when assessed with mass spectrometry. Proteins that were upregulated in the 3 independent OCD cases relative to controls are shown in red and the relative down regulation compared to the geometric mean after Log2 transformation is shown in blue. B Pathway analysis identified the the complement system. The protein interaction network is shown where nodes are coloured according to effect size of differential expression in cases versus controls. The increased border thickness of SERPING1, C1R, C4B, CFH, C8G and C9 indicates p-value < 0.05. *Proteins without representation were removed from the pathway or marked with an asterisk in cases of particular importance to pathway function.

Back to article page