Table 2 Differences in Connectivity (ANCOVA).

Connection	Patients (m[sd])		Healthy controls		F (df1,df2)	η²	p
Connection	Z	SE	Z	SE	F (df1,df2)	η²	p
All patients vs. HC
posterior Insula (l)—Thalamus (r)	0.18	0.02	0.11	0.02	15.44 (1,533)	0.03	.037
PD/AG vs HC
pregenual ACC (l)—PAG (r)	0.07	0.01	0.12	0.01	−12.32 (1,248)	−0.05	.024
subgenual ACC (r)—dmPFC (r)	0.53	0.02	0.60	0.02	−10.89 (1,248)	−0.05	.043
posterior Insula (r)—Thalamus (r)	0.22	0.02	0.11	0.02	18.84 (1,248)	0.07	0.008
posterior Insula (r)—Thalamus (l)	0.20	0.01	0.11	0.02	14.67 (1,248)	0.06	0.009
posterior Insula(l)—Thalamus (r)	0.21	0.02	0.11	0.02	15.60 (1,248)	0.06	0.008
Hippocampus (r)—Thalamus (r)	0.20	0.02	0.10	0.02	16.24 (1,248)	0.06	0.008
Hippocampus (r)—Thalamus (l)	0.21	0.02	0.11	0.02	14.59 (1,248)	0.06	0.009
Hippocampus (l)—Thalamus (r)	0.20	0.02	0.10	0.02	12.18 (1,248)	0.05	0.024
Amygdala (l)—Thalamus (l)	0.19	0.01	0.09	0.02	16.06 (1,248)	0.06	0.008
Amygdala (l)—Thalamus (r)	0.16	0.02	0.05	0.02	17.39 (1,248)	0.07	0.008
SAD vs. HC
posterior Insula (l)—OFC (r)	−0.07	0.02	−0.16	0.02	18.83 (1,189)	0.09	0.009
SP vs. HC
No significant findings

Pairs of ROIs that differed between diagnostic groups. Z—Fishers-Z transformed correlation, SE—standard error, F—F-statistic, η²—effect size, p—significance level, (r) = right hemisphere, (l) = left hemisphere.

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