Fig. 6: Association of meta-analytic findings with neurotransmitter receptor/transporter maps. | Molecular Psychiatry

Fig. 6: Association of meta-analytic findings with neurotransmitter receptor/transporter maps.

From: Convergent functional effects of antidepressants in major depressive disorder: a neuroimaging meta-analysis

Fig. 6

A The parcellated and Z-scored PET maps of neurotransmitter receptor/transporter (NRT) are shown. Red outline indicates the left dorsolateral prefrontal cortex (L DLPFC) convergent cluster identified in the activation likelihood estimation meta-analysis on Treated > Untreated experiments. B Median normalized density of NRTs in L DLPFC cluster. None of the NRTs showed significantly more extreme normalized density in this cluster compared to a null distribution created using variogram-based surrogate maps and after false discovery rate adjustment at 5%. C Pearson correlation of parcellated convergent connectivity map with the NRT maps. None of the correlations were significant using variogram-based surrogates and after false discovery rate adjustment at 5%.

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