Table 2 Activation Likelihood Estimation (ALE) analyses on the effects of antidepressants in major depressive disorder.

From: Convergent functional effects of antidepressants in major depressive disorder: a neuroimaging meta-analysis

Experiments

Comparison

N

Min pcFWEa

Convergence

All

All

30

0.387

-

Treated > Untreated

20

0.005

L DLPFC

Treated < Untreated

21

0.615

-

Based on modality

Rest

All

12

0.052

-

Task

All

19

0.970

-

Based on treatment and clinical setting

Excluding ketamine

All

23

0.486

-

Treated > Untreated

14

0.024

L DLPFC, R DLPFC

Treated < Untreated

16

0.464

-

Pre- versus post-treatment effects

All

24

0.294

-

Treated > Untreated

18

0.004

L DLPFC, R DLPFC

Treated < Untreated

20

0.469

-

Treatment duration > 4 weeks

All

20

0.472

-

Treated > Untreated

12

0.010

R mSFG

Treated < Untreated

14

0.189

-

Response in ≥50% of subjects

All

19

0.614

-

Treated > Untreated

12

0.007

L SMG, R DLPFC

Treated < Untreated

15

0.357

-

  1. cFWE cluster-wise family-wise error, L left, R right, DLPFC dorsolateral prefrontal cortex, mSFG medial superior frontal gyrus, SMG supramarginal gyrus.
  2. aBold p-values indicate statistical significance.
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