Fig. 3: Reduced inhibitory synaptic inputs to CA1 PCs from iCKO mice. | Molecular Psychiatry

Fig. 3: Reduced inhibitory synaptic inputs to CA1 PCs from iCKO mice.

From: Dysregulation of neuropilin-2 expression in inhibitory neurons impairs hippocampal circuit development and enhances risk for autism-related behaviors and seizures

Fig. 3

A Representative spontaneous inhibitory postsynaptic current (sIPSC) recordings in control and iCKO mice. Note that events are less frequent in iCKO mice. B Cumulative distribution of sIPSC interevent intervals show a right shift in iCKO mice suggesting a lower frequency of sIPSC compared to controls (n = 8–9 cells from 3 mice / group, p = 0.0037, Kolmogorov-Smirnov test). Inset; the sIPSC amplitudes were larger in iCKO mice (p = 0.0071, unpaired t-test). C Representative miniature inhibitory postsynaptic currents (mIPSC) in control and iCKO mice. D Cumulative distribution of mIPSC interevent intervals show a right shift in iCKO mice indicating a lower frequency of mIPSC compared to controls (n = 7–8 cells from 3 mice/group, p < 0.0001, Kolmogorov-Smirnov test). Inset; the mIPSC amplitudes were not different between control and iCKO mice. Representative averaged sIPSC/mIPSC traces are included for comparison.

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