Table 1 AD-associated genes differentially expressed in the hippocampus and basolateral amygdala of APP/Tau mice.

 CD33 molecule

CD33

0.909

0.0002

0.811

0.0112

Carbohydrate and protein binding

 Cell adhesion associated, oncogene regulated^*

CDON

−0.407

0.0129

0.044

0.8796

Protein binding

 FERM domain containing kindlin 2^**

FERMT2

0.072

0.2276

0.160

0.0355

Actin, integrin, and protein kinase binding

 Spondin 1

SPON1

−0.195

0.0208

−0.468

0.0499

Extracellular matrix structural constituent

 Proline rich coiled-coil 2C^*

PRRC2C

−0.157

0.0357

−0.200

0.2183

RNA binding

 Zinc finger CW-type and PWWP domain containing 1^*

ZCWPW1

0.220

0.0625

−0.085

0.6838

Methylated histone and zinc ion binding

 CD2 associated protein^*

CD2AP

0.159

0.0409

0.194

0.2039

Protein binding

 GRB2 associated binding protein 2^*

GAB2

0.251

0.0018

0.077

0.6138

Transmembrane receptor protein tyrosine kinase adaptor activity

 Inositol polyphosphate-5-phosphatase D

INPP5D

0.911

1.76E-07

0.524

0.0031

Inositol phosphatase activity

 IQ motif containing GTPase activating protein 2

IQGAP2

−0.337

0.0798

−0.681

0.0159

Actin binding

 Myelin protein zero like 1^**

MPZL1

0.188

0.1824

0.300

0.0347

Structural molecule activity

 Ras and Rab interactor 3^*

RIN3

0.529

0.0098

0.237

0.5371

GTPase activator activity

 Rho GTPase activating protein 20^*

ARHGAP20

−0.338

0.0006

−0.044

0.8427

GTPase activator activity

 Serine/threonine kinase 32B^*

STK32B

−0.412

0.0383

−0.069

0.7908

Protein serine/threonine kinase activity

 Bridging integrator 1^*

BIN1

0.115

0.0115

−0.128

0.4945

Actin filament binding

 Cordon-bleu WH2 repeat protein**

COBL

−0.002

0.9956

−0.286

0.0663

Actin monomer binding

 CUB and Sushi multiple domains 1^*

CSMD1

−0.315

0.0146

−0.224

0.3286

Protein binding

 DLC1 Rho GTPase activating protein^**

DLC1

−0.018

0.8286

−0.426

0.0880

GTPase activator activity

 Cytochrome c, somatic^*

CYCS

−0.129

0.0797

−0.108

0.4746

Electron transfer activity

 ADAM metallopeptidase with thrombospondin type 1 motif 20^**

ADAMTS20

−0.040

0.8181

0.344

0.0244

Metalloendopeptidase activity

 Thrombospondin type 1 domain containing 4^**

THSD4

−0.261

0.3363

−0.933

0.0400

Hydrolase activity

 Clusterin

CLU

0.685

0.0015

0.477

0.0059

Aβ and misfolded protein binding

 Protein tyrosine kinase 2 beta^*

PTK2B

−0.274

0.0687

−0.110

0.3080

ATP binding

 SLP adaptor and CSK interacting membrane protein^*

SCIMP

2.519

0.0067

2.527

NA

Molecular adaptor activity

 Triggering receptor expressed on myeloid cells 2

TREM2

1.849

4.88E-08

1.176

0.0025

Aβ, lipid, and protein binding

 Triggering receptor expressed on myeloid cells like 2^*

TREML2

1.424

7.83E-05

0.389

0.4646

Signaling receptor activity

 Aldehyde oxidase 1

AOX1

0.605

5.12E-05

0.616

0.0011

Aldehyde oxidase activity

 Apolipoprotein C1

APOC1

1.640

0.0002

1.093

0.0461

Lipid binding

 Apolipoprotein E

APOE

0.744

0.0140

0.556

0.0049

Lipid binding

 Enoyl-CoA hydratase domain containing 3

ECHDC3

0.914

0.0048

1.207

0.0027

Lyase activity

 Phospholipase C gamma 2

PLCG2

0.509

0.0124

0.389

0.0982

Phosphatidylinositol and phospholipase activity

 Sortilin related receptor 1^*

SORL1

−0.200

4.69E-05

−0.157

0.1056

Aβ, low-density lipoprotein particle, neuropeptide and GTPase binding

 Thromboxane A synthase 1

TBXAS1

1.116

0.0010

1.040

3.08E-06

Oxidoreductase activity

 UDP glucuronosyltransferase family 1 member A10

UGT1A10

1.562

1.19E-08

1.005

0.0001

Glucuronosyltransferase activity

 UDP glucuronosyltransferase family 1 member A8

UGT1A8

1.569

1.15E-08

0.990

9.72E-05

Glucuronosyltransferase activity

 F-box and leucine-rich repeat protein 7^*

FBXL7

−0.489

0.0437

0.066

0.8875

Protein binding and ubiquitination

 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1^*

HECW1

−0.211

0.0285

−0.289

0.1478

Ubiquitin protein ligase activity

 Heparan sulfate-glucosamine 3-sulfotransferase 1

HS3ST1

0.259

0.0014

0.382

0.0363

Sulfotransferase activity

 Rhomboid 5 homolog 1^*

RHBDF1

0.364

0.0018

0.069

0.7152

Growth factor binding

 Sequestosome 1^*

SQSTM1

0.108

0.0355

−0.024

0.8687

Protein kinase and ubiquitin binding

 SEC24 homolog B, COPII coat complex component

SEC24B

−0.111

0.0150

−0.120

0.0843

SNARE and zinc ion binding

 Transglutaminase 6^*

TGM6

−1.436

0.0501

−0.852

NA

Protein-glutamine gamma-glutamyltransferase activity

 USP6 N-terminal like

USP6NL

0.181

0.0521

−0.366

0.0726

GTPase activator activity

 Dmx like 1^*

DMXL1

−0.186

0.0085

−0.087

0.4498

Vacuolar acidification

 Neuronal calcium sensor 1^*

NCS1

−0.197

0.0298

−0.051

0.4838

Calcium binding

 Na+/K+ transporting ATPase interacting 2^*

NKAIN2

−0.145

0.0029

−0.123

0.2962

Sodium/potassium-transporting ATPase activity

 Phosphodiesterase 7B^*

PDE7B

−0.352

0.0042

0.442

0.4354

c-AMP phosphodiesterase activity

 Phosphatidylinositol binding clathrin assembly protein^*

PICALM

0.104

0.0952

0.022

0.8404

Aβ, SNARE, clathrin, and GTPase binding

 Solute carrier family 24 member 4^*

SLC24A4

−0.257

0.0121

−0.086

0.7272

Calcium/potassium/sodium transporter activity

 Solute carrier family 4 member 8^*

SLC4A8

−0.152

0.0227

−0.132

0.3902

Sodium/bicarbonate/chloride transporter activity

 Tetraspanin 13^*

TSPAN13

−0.211

0.0375

−0.128

0.3426

Calcium channel regulator activity

 AHNAK nucleoprotein^*

AHNAK

0.793

0.0072

0.234

0.3389

RNA and protein binding

 BCAS3 microtubule associated cell migration factor^*

BCAS3

−0.122

0.0286

2.299

NA

Acetyltransferase activator activity

 BCL3 transcription coactivator^*

BCL3

2.499

8.48E-06

1.203

0.1014

DNA-binding transcription factor binding

 CUGBP Elav-like family member 1^*

CELF1

−0.134

0.0681

−0.053

0.4822

RNA binding

 General transcription factor IIH subunit 3^**

GTF2H3

−0.089

0.2043

0.198

0.0294

Metal ion binding

 Histone deacetylase 9

HDAC9

−0.206

0.0724

−0.386

0.0449

DNA-binding transcription factor binding

 ST18 C2H2C-type zinc finger transcription factor

ST18

−0.229

0.0346

0.389

0.0315

DNA-binding transcription factor activity, RNA polymerase II-specific

 Ataxin 7 like 1^*

ATXN7L1

−0.141

0.0086

0.022

0.9034

Protein binding

 Leucine zipper protein 2

LUZP2

−0.187

0.0565

−0.251

0.0840

Extracellular region

 Membrane spanning 4-domains A4A

MS4A4A

0.705

0.0989

1.178

0.0588

Protein binding

 Protein phosphatase 1 regulatory subunit 37^*

PPP1R37

−0.096

0.0642

−0.040

0.6481

Protein phosphatase inhibitor activity

 Transmembrane and coiled-coil domains 4

TMCO4

0.708

0.0002

0.467

0.0063

Protein binding