Table 2 The comparison of key demographic and clinical characteristics between patients with (n = 36) and without dementia (n = 103) during follow-up.
Total sample | Dementia (n = 36) | No Dementia (n = 103) | Test statistic; p-value | ||
|---|---|---|---|---|---|
Numerical measures | |||||
Age (mean, SD) | 76.23(6.77) | 78.86(7.16) | 75.31(6.42) | t = −2.77; p = 0.006 | |
Years of education (median, IQR) | 9(8–11) | 8(7–10) | 9(8–12) | z = 1.35; p = 0.18 | |
BMI (median, IQR) | 23.68(21.60–26.22) | 24.45 (21.80–27.36) | 23.42 (21.47–26.18) | z = −1.05; p = 0.30 | |
Age of first onset of depression (median, IQR) | 60(40–74) | 65(46–77) | 60(38–73.5) | z = −1.15; p = 0.25 | |
MADRS (mean, SD) | 26.61(853) | 25.17(9.70) | 27.13(8.06) | t = 1.19; p = 0.24 | |
MADRS change post-treatment (absolute score change - mean,SD) | 16.84(9.54) | 13.38(9.41) | 18.12 (9.31) | t = −2.53; p = 0.013 | |
MMSE (median, IQR) | 27(25–29) | 25(22–27) | 28(26–29) | z = 3.65; p < 0.01 | |
Categorical measures | |||||
N (valid %) | χ²(df); p-value/ Fisher’s exact p-value | ||||
Gender | Female | 112 (73.7) | 25(69.4) | 79(76.7) | χ²(1)* = 0.75; p = 0.39 |
Marital status | Married | 67(39.6) | 18(36.7) | 47(45.2) | Fisher’s exact = 0.07 |
Widowed | 71(42.01) | 24(49) | 36(34.6) | ||
Single | 13(7.7) | 1(2.04) | 11(10.6) | ||
Divorced/Separated | 18(10.7) | 6(12.24) | 10(9.6) | ||
Smoking | Current smoker | 25 (18.66) | 4 (11.11) | 21 (21.43) | χ²(1)* = 1.85; p = 0.17 |
Past history of depression | 1 vs 0 | 104(68.9) | 25(69.4) | 69(67.7) | χ²(1)* = 0.04; p = 0.84 |
Late-onset depression (cut-off 60) | LOD vs EOD | 70 (52.63) | 18 (54.55) | 52(52.0) | χ²(1)* = 0.06; p = 0.8 |
ApoE genotype ε4 | ε4 carriership | 51(37.5) | 17(53.1) | 29(31.9) | χ²(1)* = 4.57; p = 0.03 |
allele | |||||
GMHR (Poor health) | Poor vs good | 74(48.68) | 22(61.11) | 42(40.78) | χ²(1)* = 4.44;p = 0.04 |
CGI | No improvement vs improvement | 37(24.50) | 12(33.33) | 16(15.69) | χ²(1)* = 5.12;p = 0.02 |
