Fig. 1: Cartoon suggesting the possible relationships between the different disease pathologies: amyloid, cleared largely by the microglia: tau, clearly largely by the ubiquitin proteasome and synuclein, cleared mainy through the lysosome.

However, these clearance pathways are not mutually exclusive, and as one fails, it overloads the other pathways pushing them to fail and cause their substrates to build up. Thus, the different pathologes need not have direct connections, but rather be indirectly connected by clearance failure.