Fig. 1: βIV spectrin AIS immunofluorescence is decreased in SCZ postmortem DLPFC. | Molecular Psychiatry

Fig. 1: βIV spectrin AIS immunofluorescence is decreased in SCZ postmortem DLPFC.

From: βIV spectrin abundancy, cellular distribution and sensitivity to AKT/GSK3 regulation in schizophrenia

Fig. 1

A Staining of NeuN and βIV spectrin in DLPFC L3b of HC and patients with SCZ. Scale bar in A-vi is 10 μm. B Zoom to AIS from A Scale bar is 5 μm. C Changes in βIV spectrin fluorescence intensity signal at the AIS (n = 288 HC, 243 SCZ), soma (n = 92 HC, 66 SCZ) and ratio of both measurements (n = 85 HC, 66 SCZ). D Profile of fluorescence intensity of βIV spectrin at the AIS of HC (gray) and SCZ (blue). E Accuracy of random forest classifier sorting of AIS fluorescence intensity. *p < 0.05 and **p < 0.01 by nested t-test (two-tailed) from n = 15 HC, 12 SCZ subjects. Each dot represents an individual cell measurement.

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