Fig. 2: Deficits of spontaneous sociability in adolescent mice with S-ketamine exposure. | Molecular Psychiatry

Fig. 2: Deficits of spontaneous sociability in adolescent mice with S-ketamine exposure.

From: S-ketamine exposure in early postnatal period induces social deficit mediated by excessive microglial synaptic pruning

Fig. 2

a Pipeline of mouse behavior recording and analysis via 3D-motion learning framework. b Social behavior atlas with distance map of all mice. c The cluster gram of social behavior modules across 4 groups of mice. d, e Volcano plot and pie chart representing the number of differential behavior modules between saline and S-ketamine groups when interacting with a familiar mouse d and a stranger mouse e. Red represents increased phenotype and blue indicates decreased phenotype. f Comparison of the fractions of social behavior modules between saline and S-ketamine groups when interacting with a familiar mouse (top) and a stranger mouse (bottom). g SBeA of differential social behaviors. h Comparison of the merging fractions of seven social behaviors when interacting with a familiar mouse (left) and a stranger mouse (right). n = 15 mice per group. Data are presented as the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001. See Supplementary Table 1 for detailed statistical information.

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