Fig. 1: Two OCD-DBS connectomes.

The ORT (A, purple) [23] and the slMFB (B,C, green) [32, 48,49,50, 70] bear a clear amount of resemblance/overlap. A The group of yellow spheres indicate actual effective slMFB DBS VATs the Freiburg cohort [18]. Note how these spheres project in proximity to but not exactly onto the ORT [23] while perfectly hitting slMFB. B Superimposition of slMFB connectome (short-range) and C, long-range. slMFB connectome taken from [32]. Inset in C shows the distinction between ORT/slMFB as such that slMFB reaches further dmPFC regions. D–F Details from upper corresponding panel but enriched with E, slMFB and F, motor MFB [39] as a third connectome. G, H View from posterior especially focussing on the connectome relations to STN, VTA and anterior limb of the internal capsule (ICa). Inset in lower panel taken from [21] showing the inferior and lateral position of the reward network in ICa. ORT and slMFB leave ICa at its deepest portion (superior to anterior commissure, ac) rather laterally. G Left ORT connectome touches STN superficially while on the right side fibers appear to enter the STN from out of the hypothalamus. Such fiber route is unphysiological according to [32, 33, 81] and presumably the result of an anatomically unsupervised fiber selection. H slMFB follows the fiber corridor and deconstructs into a medial (mesolimbic) and lateral (mesocortical) portion.