Fig. 3: Correlation of stimulated electrode contact proximity to respective anatomical structures and anti-OCD efficacy (details in methods). | Molecular Psychiatry

Fig. 3: Correlation of stimulated electrode contact proximity to respective anatomical structures and anti-OCD efficacy (details in methods).

From: Deconstructing a common pathway concept for Deep Brain Stimulation in the case of Obsessive-Compulsive Disorder

Fig. 3

Green regression line, MFB only; blue regression line amSTN only. Red regression line indicates joint analysis. Grenoble (blue crosses): Strong correlation for ORT AND for STN. Freiburg (green dots): Strong correlations for mesocortical (cort) slMFB, limbic & mesocortical(limb+cort) slMFB and motor MFB. Joint: Statistically significant findings for MFB (motor) and ORT. Joint correlation for mtrMFB appears almost equally strong as ORT (p < 0.006 vs. p < 0.001). Remember that Grenoble cohort was used to define ORT, introducing a certain bias for this analysis. Dots and crosses represent left and right hemispheres as such that each patient is represented by two dots or crosses, respectively. Legend: a.u., arbitrary unit (higher number indicates higher structure density moving toward center); slMFB, superolateral medial forebrain bundle; cort, mesocortical part; limb, mesolimbic part; mtrMFB, motor MFB; ORT OCD, unified connectomic tract for OCD; P1 cortico-pontine tract (Arnold’s Bundle), STN subthalamic nucleus, VTA ventral tegmental area.

Back to article page