Fig. 1: Dorsal hippocampal fear memory is specific to context and not conditioned stimuli (CS).
From: Hippocampal ensembles regulate circuit-induced relapse of extinguished fear
A Experimental design of adult male and female rats that were surgically implanted with cannulae aimed at the dorsal hippocampus (DH). After recovery, animals were infused with vehicle (VEH) or the N-methyl-D-aspartate (NMDA) receptor antagonist, D,L-2-amino-5-phosphonovalerate (APV), just prior to auditory fear conditioning (VEH, n = 7; APV, n = 6). After conditioning, animals underwent a context retrieval test followed 24 h later by an auditory conditioned (CS) retrieval test. B Left panel displays percentage of freezing [mean ± standard error of the mean (SEM)] during the baseline (BL) and final conditioning CS. Right panel displays percentage of freezing (mean ± SEM) during the context and tone retrieval. Female animals are represented by white-filled and light orange-filled triangles, while male animals are represented by gray-filled and dark orange-filled diamonds in the bar graphs. **p < 0.01. C Representative location of the injector tip of the cannula tract within the DH, of each animal included in the final analyses. Atlas figures are adapted from Swanson (2018).
