Fig. 1: Age-dependent impairments in spatial working memory and object recognition memory in 5xFAD mice. | Molecular Psychiatry

Fig. 1: Age-dependent impairments in spatial working memory and object recognition memory in 5xFAD mice.

From: Chronic social isolation-unpredictable stress induces early-onset cognitive deficits and exacerbates Aβ accumulation in the 5xFAD mouse model of Alzheimer’s disease

Fig. 1

A Y-maze spontaneous alternation test. (A1) Schematic of the Y-maze test. (A2–A3) Spontaneous alternation rate (left) and total arm entries (right) of male 5xFAD mice and WT littermate control mice tested at 3–6-months old (A2) and 9–10-months old (A3). A2: WT, n = 19; 5xFAD, n = 26. A3: WT, n = 11; 5xFAD, n = 14. *P < 0.05, *P < 0.01 compared with WT mice. B Novel object recognition (NOR) test. (B1) Schematic of the experimental procedure of the NOR test. (B2) Trial 1 with a 2-h retention interval. Left, representative images of heat maps depicting the time spent by the mice in the test arena. Middle, exploration time between familiar (F) and novel object 1 (N1). Right, discrimination index. (B3) Trial 2 with a 24-h retention interval. Left, representative images of heat maps depicting the time spent by the mice in the test arena. Middle, exploration time between familiar (F) and novel object 2 (N2). Right, discrimination index. n = 7–11 male mice per group. For exploration time, **P < 0.01, paired t-test compared between familiar and novel object. For discrimination index, **P < 0.01 compared with WT mice.

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