Fig. 5: Chronic social isolation-unpredictable stress induces the onset of cognition deficits in young 5xFAD mice. | Molecular Psychiatry

Fig. 5: Chronic social isolation-unpredictable stress induces the onset of cognition deficits in young 5xFAD mice.

From: Chronic social isolation-unpredictable stress induces early-onset cognitive deficits and exacerbates Aβ accumulation in the 5xFAD mouse model of Alzheimer’s disease

Fig. 5

A Timeline of experimental procedures. B Body weight changes before and after exposure to 10 days of social isolation and unpredictable stress (SIUS). C Spontaneous alternation rate (left) and total arm entries (right) in the Y-maze test. WT-Ctrl: male, n = 12, female, n = 9; WT-SIUS: male, n = 7, female, n = 10; 5xFAD-Ctrl: male, n = 7, female, n = 10; 5xFAD-SIUS: male, n = 7, female, n = 7. D Exploration time and discrimination index in the novel objection recognition test with a 2-h retention interval. E Exploration time and discrimination index in the novel objection recognition test with a 24-h retention interval. WT-Ctrl: male, n = 8, female, n = 7; WT-SIUS: male, n = 8, female, n = 9; 5xFAD-Ctrl: male, n = 7, female, n = 10; 5xFAD-SIUS: male, n = 7, female, n = 7. *P < 0.05, **P < 0.01, ***P < 0.001, #P = 0.051. ns, not significant. Control, Ctrl; social isolation and unpredictable stress, SIUS.

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