Fig. 6: Chronic social isolation-unpredictable stress accelerates Aβ plaque deposition in 5xFAD mice. | Molecular Psychiatry

Fig. 6: Chronic social isolation-unpredictable stress accelerates Aβ plaque deposition in 5xFAD mice.

From: Chronic social isolation-unpredictable stress induces early-onset cognitive deficits and exacerbates Aβ accumulation in the 5xFAD mouse model of Alzheimer’s disease

Fig. 6

Representative coronal brain sections showing staining of Aβ plaques and quantitative analysis of Aβ plaque load in the entorhinal cortex A, hippocampus B and mPFC C of 5xFAD mice under control (Ctrl) or chronic social isolation and unpredictable stress (SIUS) conditions. n = 8–10 sections from 4–5 mice per sex per group. Scale bar = 200 µm. *P < 0.05, **P < 0.01, ***P < 0.001 compared with Ctrl mice.

Back to article page