Fig. 1: Situating adolescence in the rodent lifespan.

Adolescence can be considered to last from weaning (generally PND 21) until rodents achieve complete sexual, behavioral, and neurobiological maturity around PND 60. It can be further divided into early (~PND 21–34), middle (~PND 35–45), and late (~PND 45–60) periods where animals exhibit different epochs of sexual development and exhibit certain behavioral and neurobiological characteristics.