Fig. 3: Synthesis of studies for behavioral or clinical response.
From: Gene expression signatures of response to fluoxetine treatment: systematic review and meta-analyses
A Individual comparisons used in meta-analysis. B Number of genes differentially expressed (top) and pathways enriched (bottom), vs. number of samples per group in each of the nine comparisons of responders vs. non-responders (q < 0.05). C Pathways identified as significantly enriched (q < 0.05) across the nine comparisons by the three meta-analysis methods. D Percentage of pathways significantly enriched in responders or non-responders from each of the Reactome categories (“Top Level”) or KEGG Database. x-axis indicates percentage of pathways from a certain category identified as enriched. E Density plot showing distribution of Vote Sums across pathways, colored by meta-analysis result. Positive scores indicate enrichment in responders, negative in non-responders. One pathway was identified as enriched by Max-P but not Fisher’s method, with Vote total +1 (Cell death signaling, not shown). F Heatmap of Normalized Enrichment Score (NES) across comparisons for pathways identified as enriched in any comparison (Fisher’s q < 0.05). Positive NES indicates enrichment in responders.
