Fig. 4: (R)-MDMA possesses desirable properties with less reinforcement.
From: 5-HT2C receptors in the nucleus accumbens constrain the rewarding effects of MDMA
a Time course of bulk DA release triggered by different doses of (R)-MDMA. b Summary data of bulk DA levels after injection of each dose of (R)-MDMA, compared with racemic MDMA (7.5 mg/kg). Repeated measures one-way ANOVA, F4,20 = 14.54, **p = 0.0066. Dunnett’s multiple comparisons test, saline vs (R)-MDMA 10 p = 0.0535, saline vs (R)-MDMA 20 p = 0.0742, saline vs (R)-MDMA 40 *p = 0.0171, saline vs (±)-MDMA 7.5 p = 0.0777. #( ± )-MDMA 7.5 data from Fig. 1. c Left, schematic of CPP procedure. Right, magnitude of CPP produced with (R)-MDMA 20. Paired, two-tailed t-test, t14 = 0.6699, p = 0.5138. d Time course of bulk 5-HT release triggered by (R)-MDMA (20 mg/kg). e Summary data of bulk 5-HT levels after injection of (R)-MDMA (20 mg/kg), compared with racemic MDMA (7.5 mg/kg). Repeated measures one-way ANOVA, F2,19 = 17.17, **p = 0.0058. Tukey’s multiple comparisons test, saline vs (R)-MDMA 20 **p = 0.0048, saline vs (±)-MDMA 7.5 ****p < 0.0001, (R)-MDMA 20 vs (±)-MDMA 7.5 p = 0.1007. #( ± )-MDMA 7.5 data from Fig. 1. f Left, schematic of 3-chamber test with (R)-MDMA. Right, effect of (R)-MDMA (20 mg/kg) on social preference in the 3-chamber assay. Unpaired, two-tailed t-test, t10 = 3.777, **p = 0.0036.
